The stores - to be opened in Las Vegas, Los Angeles, Phoenix and San Diego - will be about 10,000 sq ft (930 sq m) in size. The shops will be smaller than conventional supermarkets to make shopping quicker and easier, according to the retailer.
Tesco will spend US$400 million (£200.3 million) a year in the US for the next five years as it expands the chain.
Fresh & Easy chief executive Tim Mason said: 'We want to sell fresh, healthy foods. It's not a beer and chips business.'
Mason said all the products sold at Fresh & Easy will be free of transfats, artificial colours and flavours. The stores will not sell cigarettes or tobacco, but will offer beer and wine.
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