The deal with the fashion icon is likely to be a marketing triumph for the business and Arcadia owner Sir Philip Green has revealed that the collection will launch spring/summer 2007 across all Topshop's stores.
Green said: 'Kate has a unique position as a true fashion icon and I look forward to helping develop Kate Moss for Topshop into a global brand.'
He added: 'Kate's appeal is not just in the UK, she has a global profile and creates a fashion statement wherever she is seen.'
Moss and Green were photographed chatting together as the pair watched models strut down the catwalk at the Topshop Unique fashion show last weekend and Green has revealed that he took a personal role in the negotiations to secure Moss's support of the partnership.
Kate has been the catalyst behind some of the retailer's top selling items including skinny jeans, which are a trend that Moss largely kicked started and have flown off the shelves at Topshop.
Celebrity endorsement and collaborations with Karl Lagerfeld and Stella McCartney have proved successful for rival chain H&M in recent months.
Topshop brand director Jane Shepherdson added: 'Kate is Britain's biggest style icon, she has a great eye and is a regular Topshop customer. Both Topshop & Kate Moss epitomise British fashion, so a collaboration between us makes perfect sense.'