Mexx, the fashion and accessories chain, is to close its 61 retail outlets in the UK.
According to reports, the withdrawal from the UK will affect 300 jobs.
Mexx, which is owned by US-based clothing group Liz Claiborne, has flagship stores on Oxford Street and Covent Garden, as well as 20 shop-in-shops in John Lewis and 38 in House of Fraser.
The withdrawal is the latest sign of the challenging state of the UK high street.
Mexx reportedly said the closures were in line with plans to divest the non-profitable elements of its portfolio.