The retailer has taken a 2,015 sq ft (185 sq m) unit on the lower level of the East Mall, the centre’s high street brand section.
Carpisa opened its first UK store on London’s Oxford Street in February last year.
Carpisa international development manager Enrico Cassero said: “Bluewater was the obvious choice for our second UK store. The store will be key to growing our portfolio.”
The retailer has also been linked to Westfield’s upcoming development in White City.
The brand was established in Naples in 1982 and has more than 300 stores throughout Italy. It is also sold in Switzerland, Russia, Malta, Israel, Saudi Arabia and Japan.
Lend Lease has also signed a further two brands to Bluewater, photo-to-canvas retailer Transform Your Images and Shakeabout Milkshakes.
The latter has taken a 300 sq ft (30 sq m) unit. The former has signed for a 270 sq ft (25 sq m) unit.
Property agency DTZ represented Lend Lease.